Designed as a pocket reference book for the practising physician, this work has already met with wide favor in the profession. In this sixth edition any material which appeared in previous editions has been completely rewritten, expanded, or thoroughly revised. New chapters have been added on asthma, syphilis, lead poisoning, anemia, endrocrine disorders, preoperative and postoperative medical treatment, and vaccine therapy. Special effort has been made to emphasize principles and to describe separately the methods recommended for putting them into practice. As an aid in correlating principles of treatment with knowledge of the mode of action of disease, salient facts have been outlined in most of the chapters as a prelude to treatment. The following well-known physicians have contributed chapters: Dr. Joseph C. Aub, Dr. Gerald Blake, Dr. John B. Hawes, 2d, Dr. Charles H. Lawrence, Dr. George R. Minot, Dr. Edwin H. Place, Dr. Francis H. Rackemann, Dr. Benjamin H. Ragle, and Dr. C. Morton Smith.