David Nathan was stunned when he first saw Dayem Saif at Children's Hospital in Boston in September 1968. Dayem was then a six-year-old with the stature of an average-sized boy of two. He wore baby shoes on his tiny feet and was unable to walk without holding his mother's hand. His color was dark yet pasty and his face horribly misshapen. The child was being ravaged by thalassemia, a life-threatening inherited disease of the blood, and one of the leading causes of disfigurement, disability, and death in children worldwide. Without effective treatment, Dayem would almost certainly die before his twentieth birthday.

Genes, Blood, and Courage is David Nathan's absorbing story of the thirty-year struggle to keep Dayem alive. "Immortal Sword" is the English translation of Dayem's Arabic name, and under Nathan's care Dayem, indeed, seems immortal. Despite his continual reluctance to follow his doctor's orders and the repeated hospitalizations that result, Dayem--the misshapen, stunted boy--survives to become a handsome, successful businessman.

In Genes, Blood, and Courage Nathan goes beyond his struggles with this seemingly immortal patient to describe in detail the emergence, over the past twenty-five years, of an entirely new force in medical care called molecular medicine. As Dayem's case illustrates, this new area of human genetic research--in which Nathan is a leading clinical investigator--promises tremendous advances in the rational diagnosis, prevention, and treatment of inherited disorders, such as thalassemia and sickle cell anemia, and even of acquired illnesses such as cancer and infectious disease.

Genes, Blood, and Courage is a celebration not just of Dayem's triumphs but also of the tremendous accomplishments and potential of the American biomedical research enterprise in the late twentieth century.

Research powers innovation and technoscientific advance, but it is due for a rethink, one consistent with its deeply holistic nature, requiring deeply human nurturing.

Research is a deeply human endeavor that must be nurtured to achieve its full potential. As with tending a garden, care must be taken to organize, plant, feed, and weed—and the manner in which this nurturing is done must be consistent with the nature of what is being nurtured.

In The Genesis of Technoscientific Revolutions, Venkatesh Narayanamurti and Jeffrey Tsao propose a new and holistic system, a rethinking of the nature and nurturing of research. They share lessons from their vast research experience in the physical sciences and engineering, as well as from perspectives drawn from the history and philosophy of science and technology, research policy and management, and the evolutionary biological, complexity, physical, and economic sciences.

Narayanamurti and Tsao argue that research is a recursive, reciprocal process at many levels: between science and technology; between questions and answer finding; and between the consolidation and challenging of conventional wisdom. These fundamental aspects of the nature of research should be reflected in how it is nurtured. To that end, Narayanamurti and Tsao propose aligning organization, funding, and governance with research; embracing a culture of holistic technoscientific exploration; and instructing people with care and accountability.

Bruce Lincoln is one of the most prominent advocates within religious studies for an uncompromisingly critical approach to the phenomenon of religion—historians of religions, he believes, should resist the preferred narratives and self-understanding of religions themselves, especially when their stories are endowed with sacred origins and authority. In Gods and Demons, Priests and Scholars, Lincoln assembles a collection of essays that both illustrates and reveals the benefits of his methodology, making a case for a critical religious studies that starts with skepticism but is neither cynical nor crude.

This book provides a systematic exposition of a group-based statistical method for analyzing longitudinal data in the social and behavioral sciences and in medicine. The methods can be applied to a wide range of data, such as that describing the progression of delinquency and criminality over the life course, changes in income over time, the course of a disease or physiological condition, or the evolution of the socioeconomic status of communities. Using real-world research data from longitudinal studies, the book explains and applies this method for identifying distinctive time-based progressions called developmental trajectories. Rather than assuming the existence of developmental trajectories of a specific form before statistical data analysis begins, the method allows the trajectories to emerge from the data itself. Thus, in an analysis of data on Montreal school children, it teases apart four distinct trajectories of physical aggression over the ages 6 to 15, examines predictors of these trajectories, and identifies events that may alter the trajectories.

Aimed at consumers of statistical methodology, including social scientists, criminologists, psychologists, and medical researchers, the book presents the statistical theory underlying the method with a mixture of intuition and technical development.