front cover of Body by Darwin
Body by Darwin
How Evolution Shapes Our Health and Transforms Medicine
Jeremy Taylor
University of Chicago Press, 2015
We think of medical science and doctors as focused on treating conditions—whether it’s a cough or an aching back. But the sicknesses and complaints that cause us to seek medical attention actually have deeper origins than the superficial germs and behaviors we regularly fault. In fact, as Jeremy Taylor shows in Body by Darwin, we can trace the roots of many medical conditions through our evolutionary history, revealing what has made us susceptible to certain illnesses and ailments over time and how we can use that knowledge to help us treat or prevent problems in the future.
 
In Body by Darwin, Taylor examines the evolutionary origins of some of our most common and serious health issues. To begin, he looks at the hygiene hypothesis, which argues that our obsession with anti-bacterial cleanliness, particularly at a young age, may be making us more vulnerable to autoimmune and allergic diseases. He also discusses diseases of the eye, the medical consequences of bipedalism as they relate to all those aches and pains in our backs and knees, the rise of Alzheimer’s disease, and how cancers become so malignant that they kill us despite the toxic chemotherapy we throw at them. Taylor explains why it helps to think about heart disease in relation to the demands of an ever-growing, dense, muscular pump that requires increasing amounts of nutrients, and he discusses how walking upright and giving birth to ever larger babies led to a problematic compromise in the design of the female spine and pelvis.  Throughout, he not only explores the impact of evolution on human form and function, but he integrates science with stories from actual patients and doctors, closely examining the implications for our health.
 
As Taylor shows, evolutionary medicine allows us think about the human body and its adaptations in a completely new and productive way. By exploring how our body’s performance is shaped by its past, Body by Darwin draws powerful connections between our ancient human history and the future of potential medical advances that can harness this knowledge.
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front cover of The Dominant Animal
The Dominant Animal
Human Evolution and the Environment
Paul R. Ehrlich and Anne H. Ehrlich
Island Press, 2008
In humanity’s more than 100,000 year history, we have evolved from vulnerable creatures clawing sustenance from Earth to a sophisticated global society manipulating every inch of it. In short, we have become the dominant animal. Why, then, are we creating a world that threatens our own species? What can we do to change the current trajectory toward more climate change, increased famine, and epidemic disease?
 
Renowned Stanford scientists Paul R. Ehrlich and Anne H. Ehrlich believe that intelligently addressing those questions depends on a clear understanding of how we evolved and how and why we’re changing the planet in ways that darken our descendants’ future. The Dominant Animal arms readers with that knowledge, tracing the interplay between environmental change and genetic and cultural evolution since the dawn of humanity. In lucid and engaging prose, they describe how Homo sapiens adapted to their surroundings, eventually developing the vibrant cultures, vast scientific knowledge, and technological wizardry we know today.
 
But the Ehrlichs also explore the flip side of this triumphant story of innovation and conquest. As we clear forests to raise crops and build cities, lace the continents with highways, and create chemicals never before seen in nature, we may be undermining our own supremacy. The threats of environmental damage are clear from the daily headlines, but the outcome is far from destined. Humanity can again adapt—if we learn from our evolutionary past.
 
Those lessons are crystallized in The Dominant Animal. Tackling the fundamental challenge of the human predicament, Paul and Anne Ehrlich offer a vivid and unique exploration of our origins, our evolution, and our future.
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front cover of The Genetic Gods
The Genetic Gods
Evolution and Belief in Human Affairs
John C. Avise
Harvard University Press, 1998

They mastermind our lives, shaping our features, our health, and our behavior, even in the sacrosanct realms of love and sex, religion, aging, and death. Yet we are the ones who house, perpetuate, and give the promise of immortality to these biological agents, our genetic gods. The link between genes and gods is hardly arbitrary, as the distinguished evolutionary geneticist John Avise reveals in this compelling book. In clear, straightforward terms, Avise reviews recent discoveries in molecular biology, evolutionary genetics, and human genetic engineering, and discusses the relevance of these findings to issues of ultimate concern traditionally reserved for mythology, theology, and religious faith.

The book explains how the genetic gods figure in our development--not just our metabolism and physiology, but even our emotional disposition, personality, ethical leanings, and, indeed, religiosity. Yet genes are physical rather than metaphysical entities. Having arisen via an amoral evolutionary process--natural selection--genes have no consciousness, no sentient code of conduct, no reflective concern about the consequences of their actions. It is Avise's contention that current genetic knowledge can inform our attempts to answer typically religious questions--about origins, fate, and meaning. The Genetic Gods challenges us to make the necessary connection between what we know, what we believe, and what we embody.

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front cover of History Within
History Within
The Science, Culture, and Politics of Bones, Organisms, and Molecules
Marianne Sommer
University of Chicago Press, 2016
Personal genomics services such as 23andMe and Ancestry.com now offer what once was science fiction: the ability to sequence and analyze an individual’s entire genetic code—promising, in some cases, facts about that individual’s ancestry that may have remained otherwise lost. Such services draw on and contribute to the science of human population genetics that attempts to reconstruct the history of humankind, including the origin and movement of specific populations. Is it true, though, that who we are and where we come from is written into the sequence of our genomes? Are genes better documents for determining our histories and identities than fossils or other historical sources?
           
Our interpretation of gene sequences, like our interpretation of other historical evidence, inevitably tells a story laden with political and moral values. Focusing on the work of Henry Fairfield Osborn, Julian Sorell Huxley, and Luigi Luca Cavalli-Sforza in paleoanthropology, evolutionary biology, and human population genetics, History Within asks how the sciences of human origins, whether through the museum, the zoo, or the genetics lab, have shaped our idea of what it means to be human. How have these biologically based histories influenced our ideas about nature, society, and culture? As Marianne Sommer shows, the stories we tell about bones, organisms, and molecules often change the world.
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front cover of How to Tame a Fox (and Build a Dog)
How to Tame a Fox (and Build a Dog)
Visionary Scientists and a Siberian Tale of Jump-Started Evolution
Lee Alan Dugatkin and Lyudmila Trut
University of Chicago Press, 2017
Tucked away in Siberia, there are furry, four-legged creatures with wagging tails and floppy ears that are as docile and friendly as any lapdog. But, despite appearances, these are not dogs—they are foxes. They are the result of the most astonishing experiment in breeding ever undertaken—imagine speeding up thousands of years of evolution into a few decades. In 1959, biologists Dmitri Belyaev and Lyudmila Trut set out to do just that, by starting with a few dozen silver foxes from fox farms in the USSR and attempting to recreate the evolution of wolves into dogs in real time in order to witness the process of domestication. This is the extraordinary, untold story of this remarkable undertaking.

Most accounts of the natural evolution of wolves place it over a span of about 15,000 years, but within a decade, Belyaev and Trut’s fox breeding experiments had resulted in puppy-like foxes with floppy ears, piebald spots, and curly tails. Along with these physical changes came genetic and behavioral changes, as well. The foxes were bred using selection criteria for tameness, and with each generation, they became increasingly interested in human companionship. Trut has been there the whole time, and has been the lead scientist on this work since Belyaev’s death in 1985, and with Lee Dugatkin, biologist and science writer, she tells the story of the adventure, science, politics, and love behind it all.  In How to Tame a Fox, Dugatkin and Trut take us inside this path-breaking experiment in the midst of the brutal winters of Siberia to reveal how scientific history is made and continues to be made today.

To date, fifty-six generations of foxes have been domesticated, and we continue to learn significant lessons from them about the genetic and behavioral evolution of domesticated animals. How to Tame a Fox offers an incredible tale of scientists at work, while also celebrating the deep attachments that have brought humans and animals together throughout time.
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front cover of The Shape of Life
The Shape of Life
Genes, Development, and the Evolution of Animal Form
Rudolf A. Raff
University of Chicago Press, 1996
Rudolf Raff is recognized as a pioneer in evolutionary developmental biology. In their 1983 book, Embryos, Genes, and Evolution, Raff and co-author Thomas Kaufman proposed a synthesis of developmental and evolutionary biology. In The Shape of Life, Raff analyzes the rise of this new experimental discipline and lays out new research questions, hypotheses, and approaches to guide its development.

Raff uses the evolution of animal body plans to exemplify the interplay between developmental mechanisms and evolutionary patterns. Animal body plans emerged half a billion years ago. Evolution within these body plans during this span of time has resulted in the tremendous diversity of living animal forms.

Raff argues for an integrated approach to the study of the intertwined roles of development and evolution involving phylogenetic, comparative, and functional biology. This new synthesis will interest not only scientists working in these areas, but also paleontologists, zoologists, morphologists, molecular biologists, and geneticists.
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