In 1989 Michael Bishop and Harold Varmus were awarded the Nobel Prize for their discovery that normal genes under certain conditions can cause cancer. In this book, Bishop tells us how he and Varmus made their momentous discovery. More than a lively account of the making of a brilliant scientist, How to Win the Nobel Prize is also a broader narrative combining two major and intertwined strands of medical history: the long and ongoing struggles to control infectious diseases and to find and attack the causes of cancer.

Alongside his own story, that of a youthful humanist evolving into an ambivalent medical student, an accidental microbiologist, and finally a world-class researcher, Bishop gives us a fast-paced and engrossing tale of the microbe hunters. It is a narrative enlivened by vivid anecdotes about our deadliest microbial enemies--the Black Death, cholera, syphilis, tuberculosis, malaria, smallpox, HIV--and by biographical sketches of the scientists who led the fight against these scourges.

Bishop then provides an introduction for nonscientists to the molecular underpinnings of cancer and concludes with an analysis of many of today's most important science-related controversies--ranging from stem cell research to the attack on evolution to scientific misconduct. How to Win the Nobel Prize affords us the pleasure of hearing about science from a brilliant practitioner who is a humanist at heart. Bishop's perspective will be valued by anyone interested in biomedical research and in the past, present, and future of the battle against cancer.

Victor Fuchs, author of Who Shall Live?, cuts through the hand wringing and the “pop” panaceas for America's current social crises in a brilliant analysis of the way we live. The facts are familiar. A doubled rate of divorce. A birth rate cut nearly in half while the percentage of illegitimate births nearly tripled. The young face dismal job prospects, and many of the old are totally dependent on the federal government.

Fuchs's economic approach shows us that the societal upheaval of American life is not created by fiat but rather emerges as millions of men and women make seemingly small choices that are constrained by their circumstances: “Should I go back to school?” “How many children should we have?” “When should I retire?” In a masterly synthesis, he shows the interrelatedness of our choices regarding family, work, health, and education throughout the life cycle. He uses the latest facts of American life to explore three major themes—the fading family, the impact of simple demographics on individual destiny, and the effect of weighing present and future costs and benefits on individual choice.

Fuchs concludes by offering innovative solutions to many contemporary problems: social security, health insurance, child care, youth unemployment, and illegitimate births. Moving beyond the outworn orthodoxies of liberalism and conservatism, he offers a clearer view of our circumstances so that readers from all walks of life can make better private choices, and contribute to more effective public policies.

A former Wisconsin high school science teacher makes the case that how and why we teach science matters, especially now that its legitimacy is under attack.

Why teach science? The answer to that question will determine how it is taught. Yet despite the enduring belief in this country that science should be taught, there has been no enduring consensus about how or why.

This is especially true when it comes to teaching scientific process. Nearly all of the basic knowledge we have about the world is rock solid. The science we teach in high schools in particular—laws of motion, the structure of the atom, cell division, DNA replication, the universal speed limit of light—is accepted as the way nature works. Everyone also agrees that students and the public more generally should understand the methods used to gain this knowledge. But what exactly is the scientific method?

Ever since the late 1800s, scientists and science educators have grappled with that question. Through the years, they’ve advanced an assortment of strategies, ranging from “the laboratory method” to the “five-step method” to “science as inquiry” to no method at all. How We Teach Science reveals that each strategy was influenced by the intellectual, cultural, and political circumstances of the time. In some eras, learning about experimentation and scientific inquiry was seen to contribute to an individual’s intellectual and moral improvement, while in others it was viewed as a way to minimize public interference in institutional science.

John Rudolph shows that how we think about and teach science will either sustain or thwart future innovation, and ultimately determine how science is perceived and received by the public.

The idea of voting is simple, but the administration of elections in ways that ensure access and integrity is complex.

In How We Vote, Kathleen Hale and Mitchell Brown explore what is at the heart of our democracy: how elections are run. Election administration determines how ballots are cast and counted, and how jurisdictions try to innovate while also protecting the security of the voting process, as well as how election officials work.

Election officials must work in a difficult intergovernmental environment of constant change and intense partisanship. Voting practices and funding vary from state to state, and multiple government agencies, the judicial system, voting equipment vendors, nonprofit groups, and citizen activists also influence practices and limit change. Despite real challenges and pessimistic media assessments, Hale and Brown demonstrate that election officials are largely successful in their work to facilitate, protect, and evolve the voting process.

Using original data gathered from state and local election officials and policymakers across the United States, Hale and Brown analyze innovations in voter registration, voting options, voter convenience, support for voting in languages other than English, the integrity of the voting process, and voting system technology. The result is a fascinating picture of how we vote now and will vote in the future.

Like Huck’s raft, the experience of American childhood has been both adventurous and terrifying. For more than three centuries, adults have agonized over raising children while children have followed their own paths to development and expression. Now, Steven Mintz gives us the first comprehensive history of American childhood encompassing both the child’s and the adult’s tumultuous early years of life.

Underscoring diversity through time and across regions, Mintz traces the transformation of children from the sinful creatures perceived by Puritans to the productive workers of nineteenth-century farms and factories, from the cosseted cherubs of the Victorian era to the confident consumers of our own. He explores their role in revolutionary upheaval, westward expansion, industrial growth, wartime mobilization, and the modern welfare state. Revealing the harsh realities of children’s lives through history—the rigors of physical labor, the fear of chronic ailments, the heartbreak of premature death—he also acknowledges the freedom children once possessed to discover their world as well as themselves.

Whether at work or play, at home or school, the transition from childhood to adulthood has required generations of Americans to tackle tremendously difficult challenges. Today, adults impose ever-increasing demands on the young for self-discipline, cognitive development, and academic achievement, even as the influence of the mass media and consumer culture has grown. With a nod to the past, Mintz revisits an alternative to the goal-driven realities of contemporary childhood. An odyssey of psychological self-discovery and growth, this book suggests a vision of childhood that embraces risk and freedom—like the daring adventure on Huck’s raft.

Finding fresh fruits and vegetables is as easy as going to the grocery store for most Americans—which makes it all too easy to forget that our food is cultivated, harvested, and packaged by farmworkers who labor for less pay, fewer benefits, and under more dangerous conditions than workers in almost any other sector of the U.S. economy. Seeking to end the public's ignorance and improve workers' living and working conditions, this book addresses the major factors that affect farmworkers' lives while offering practical strategies for action on farmworker issues.

The contributors to this book are all farmworker advocates—student and community activists and farmworkers themselves. Focusing on workers in the Southeast United States, a previously understudied region, they cover a range of issues, from labor organizing, to the rise of agribusiness, to current health, educational, and legal challenges faced by farmworkers. The authors blend coverage of each issue with practical suggestions for working with farmworkers and other advocates to achieve justice in our food system both regionally and nationally.

In Human Documents, Robert Gardner introduces the work of photographers with whom he has worked over a period of nearly fifty years under the auspices of the Film Study Center at Harvard. Their images achieve the status of what Gardner calls “human documents”: visual evidence that testifies to our shared humanity. In images and words, the book adds to the already significant literature on photography and filmmaking as ways to gather both fact and insight into the human condition. In nearly 100 images spanning geographies and cultures including India, New Guinea, Ethiopia, and the United States, Human Documents demonstrates the important role photography can play in furthering our understanding of human nature and connecting people through an almost universal visual language.

Author and cultural critic Eliot Weinberger contributes the essay “Photography and Anthropology (A Contact Sheet),” in which he provides a new and intriguing context for viewing and thinking about the images presented here.

With photographs by Michael Rockefeller, Robert Gardner, Kevin Bubriski, Adelaide de Menil, Christopher James, Jane Tuckerman, Susan Meiselas, and Alex Webb.

This is a landmark introduction to the facts and hopes of gene therapy: an exciting, albeit controversial, technique that could bring about a new age in medical treatment. Modern medicine has had relatively little to offer children with disorders such as thalassemia and severe combined immune deficiency. Many of these young patients still face repeated hospitalizations and, often, an early death. In gene therapy, a child with life-threatening genetic disease caused by a defect in a single gene will he treated with the gene’s normal counterpart. Successful development of somatic cell gene therapy is potentially the most effective new therapeutic approach to helping these children lead normal lives.

With unusual clarity of style, Eve K. Nichols (author of the acclaimed Mobilizing Against AIDS) explores the potential for gene therapy and identifies those who are candidates for it. She reviews methods for diagnosing genetic diseases and evaluates current forms of therapy. Having provided a biomedical background for understanding somatic cell gene therapy, Nichols takes a thoughtful look at complex and sensitive issues surrounding ethical, economic, and policy aspects of manipulating human genes. A straightforward analysis of the current limitations and future potential of gene therapy concludes her broadly accessible account.

This book is is derived from the annual session of the prestigious Institute of Medicine. Distinguished participants in this meeting, such as Leon Rosenberg (Dean of the Yale Medical School), Philip Leder (Harvard Medical School), David Martin (Vice President, Genentech, Inc.), James Wyngaarden (Director of the National Institutes of Health), and LeRoy Walters (Director of the Center for Bioethics, Georgetown University), have contributed expert perspectives that will establish this book as a standard of excellence for future studies. A preface by Frank Press, President of the National Academy of Sciences, provides an insightful overview of this promising new therapy.

Since before recorded history, people have congregated near water. But as growing populations around the globe continue to flow toward the coasts on an unprecedented scale and climate change raises water levels, our relationship to the sea has begun to take on new and potentially catastrophic dimensions. The latest generation of coastal dwellers lives largely in ignorance of the history of those who came before them, the natural environment, and the need to live sustainably on the world’s shores. Humanity has forgotten how to live with the oceans.

In this bracing and original book, Geoffrey Galt Harpham argues that today’s humanities are an invention of the American academy in the years following World War II, when they were first conceived as an expression of American culture and an instrument of American national interests. The humanities portray a “dream of America” in two senses: they represent an aspiration of Americans since the first days of the Republic for a state so secure and prosperous that people could enjoy and appreciate culture for its own sake; and they embody in academic terms an idealized conception of the American national character.  Although they are struggling to retain their status in America, the concept of the humanities has spread to other parts of the world and remains one of America's most distinctive and valuable contributions to higher education.

The Humanities and the Dream of America explores a number of linked problems that have emerged in recent years: the role, at once inspiring and disturbing, played by philology in the formation of the humanities; the reasons for the humanities’ perpetual state of “crisis”; the shaping role of philanthropy in the humanities; and the new possibilities for literary study offered by the subject of pleasure. Framed by essays that draw on Harpham’s pedagogical experiences abroad and as a lecturer at the U.S. Air Force Academy, as well as his vantage as director of the National Humanities Center, this book provides an essential perspective on the history, ideology, and future of this important topic.

Millions of immigrants were drawn to American shores, not by the mythic streets paved with gold, but rather by its tables heaped with food. How they experienced the realities of America’s abundant food—its meat and white bread, its butter and cheese, fruits and vegetables, coffee and beer—reflected their earlier deprivations and shaped their ethnic practices in the new land.

Hungering for America tells the stories of three distinctive groups and their unique culinary dramas. Italian immigrants transformed the food of their upper classes and of sacred days into a generic “Italian” food that inspired community pride and cohesion. Irish immigrants, in contrast, loath to mimic the foodways of the Protestant British elite, diminished food as a marker of ethnicity. And East European Jews, who venerated food as the vital center around which family and religious practice gathered, found that dietary restrictions jarred with America’s boundless choices.

These tales, of immigrants in their old worlds and in the new, demonstrate the role of hunger in driving migration and the significance of food in cementing ethnic identity and community. Hasia Diner confirms the well-worn adage, “Tell me what you eat and I will tell you what you are.”

Food was a critical front in the Cold War battle for Asia. “Where Communism goes, hunger follows” was the slogan of American nation builders who fanned out into the countryside to divert rivers, remodel villages, and introduce tractors, chemicals, and genes to multiply the crops consumed by millions. This “green revolution” has been credited with averting Malthusian famines, saving billions of lives, and jump-starting Asia’s economic revival. Bono and Bill Gates hail it as a model for revitalizing Africa’s economy. But this tale of science triumphant conceals a half century of political struggle from the Afghan highlands to the rice paddies of the Mekong Delta, a campaign to transform rural societies by changing the way people eat and grow food.

The ambition to lead Asia into an age of plenty grew alongside development theories that targeted hunger as a root cause of war. Scientific agriculture was an instrument for molding peasants into citizens with modern attitudes, loyalties, and reproductive habits. But food policies were as contested then as they are today. While Kennedy and Johnson envisioned Kansas-style agribusiness guarded by strategic hamlets, Indira Gandhi, Marcos, and Suharto inscribed their own visions of progress onto the land.

Out of this campaign, the costliest and most sustained effort for development ever undertaken, emerged the struggles for resources and identity that define the region today. As Obama revives the lost arts of Keynesianism and counter-insurgency, the history of these colossal projects reveals bitter and important lessons for today’s missions to feed a hungry world.

High blood pressure is one of our most severe public health problems, and any national health policy must take account of the dilemmas posed by hypertension. This disease is widespread in the United States, affecting between 10 and 30 percent of the adult population. Of the 24 million Americans so afflicted, only about three million are thought to be adequately treated; yet treatment of all hypertensives would cost perhaps five billion dollars a year.

In their ground-breaking study, Weinstein and Stason apply the tools of cost-benefit analysis to examine the policy implications of existing approaches to hypertension. Their conclusions have important consequences for allocating the resources available to combat the disease, and they identify the salient questions to be answered by new research. The authors' recommendations would lead to significant changes in current approaches (the much-publicized effort to screen for new cases, for instance). They suggest that criteria for case-finding and treatment be radically altered to take account of differences in the complications of high blood pressure as a function of age, sex, and race. They stress patient compliance as the single most important factor in reducing deaths—considerably more important right now than screening. Their research priorities include: determining the extent to which early or mild hypertension affects the rate of complication; pinning down the role that side-effects of medication play in the demonstrably poor adherence of patients to treatment; and developing alternative programs to improve patient adherence.

Ideal for classroom use, this anthology of original essays by the leading authorities on women’s comedy surveys the disorderly, subversive, and unruly performances of women comics from silent film to contemporary multimedia

Winner, Susan Koppleman Award for Best Anthology, Multi-Authored, or Edited Book in Feminist Studies, Popular and American Culture Associations (PACA), 2017

Amy Schumer, Samantha Bee, Mindy Kaling, Melissa McCarthy, Tig Notaro, Leslie Jones, and a host of hilarious peers are killing it nightly on American stages and screens large and small, smashing the tired stereotype that women aren’t funny. But today’s funny women aren’t a new phenomenon—they have generations of hysterically funny foremothers. Fay Tincher’s daredevil stunts, Mae West’s linebacker walk, Lucille Ball’s manic slapstick, Carol Burnett’s athletic pratfalls, Ellen DeGeneres’s tomboy pranks, Whoopi Goldberg’s sly twinkle, and Tina Fey’s acerbic wit all paved the way for contemporary unruly women, whose comedy upends the norms and ideals of women’s bodies and behaviors.

Hysterical! Women in American Comedy delivers a lively survey of women comics from the stars of the silent cinema up through the multimedia presences of Tina Fey and Lena Dunham. This anthology of original essays includes contributions by the field’s leading authorities, introducing a new framework for women’s comedy that analyzes the implications of hysterical laughter and hysterically funny performances. Expanding on previous studies of comedians such as Mae West, Moms Mabley, and Margaret Cho, and offering the first scholarly work on comedy pioneers Mabel Normand, Fay Tincher, and Carol Burnett, the contributors explore such topics as racial/ethnic/sexual identity, celebrity, stardom, censorship, auteurism, cuteness, and postfeminism across multiple media. Situated within the main currents of gender and queer studies, as well as American studies and feminist media scholarship, Hysterical! masterfully demonstrates that hysteria—women acting out and acting up—is a provocative, empowering model for women’s comedy.